Protein Kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The kiwifruit genome contains more than 1000 predicted protein kinase genes and they constitute about 2.5 % of all kiwifruit genes. Kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.

Potential protein kinases and phosphatases were predicted and annotated from http://ekpd.biocuckoo.org/advance.php

AGC AGC/Akt AGC/MAST AGC/NDR AGC/PDK1 AGC/PKA AGC/RSK Atypical/ABC1 Atypical/PDHK
Atypical/PIKK Atypical/RIO CAMK CAMK/CAMK1 CAMK/CAMKL CK1 CK1/CK1 CMGC CMGC/CDK
CMGC/CLK CMGC/DYRK CMGC/GSK CMGC/MAPK CMGC/RCK CMGC/SRPK Others Others/Aur Others/Bud32
Others/NAK Others/NEK Others/PEK Others/TLK Others/TTK Others/ULK Others/VPS15 Others/WEE Others/WNK
STE STE/STE11 STE/STE20 STE/STE7 TK TK/Fer TKL TKL/IRAK TKL/MLK

In molecular biology, the ACT domain is a protein domain that is found in a variety of proteins involved in metabolism. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. The ACT domain is named after three of the proteins that contain it: aspartate kinase, chorismate mutase and TyrA. The archetypical ACT domain is the C-terminal regulatory domain of 3-phosphoglycerate dehydrogenase (3PGDH), which folds with a ferredoxin-like topology. A pair of ACT domains form an eight-stranded antiparallel sheet with two molecules of allosteric inhibitor serine bound in the interface. Biochemical exploration of a few other proteins containing ACT domains supports the suggestions that these domains contain the archetypical ACT structure.

Protein name Gene name Description Pathway Interaction
Protein name Gene name Description Pathway Interaction
Ach00g016651.1Ach00g016651Uncharacterized protein0
Ach00g016841.1Ach00g016841Posttranslational modification, protein turnover, chaperones0
Ach00g311981.1Ach00g311981Uncharacterized protein0
Ach00g375531.1Ach00g375531Uncharacterized protein0
Ach00g479701.2Ach00g479701Posttranslational modification, protein turnover, chaperones0
Ach04g469931.2Ach04g469931Posttranslational modification, protein turnover, chaperones0
Ach05g193391.1Ach05g193391Posttranslational modification, protein turnover, chaperones0
Ach06g043851.1Ach06g043851Posttranslational modification, protein turnover, chaperones0
Ach06g169651.2Ach06g169651Posttranslational modification, protein turnover, chaperones0
Ach07g179501.2Ach07g179501Posttranslational modification, protein turnover, chaperones0
Ach08g066451.1Ach08g066451Uncharacterized protein0
Ach09g174231.2Ach09g174231Uncharacterized protein0
Ach11g128221.2Ach11g128221Uncharacterized protein0
Ach14g317391.2Ach14g317391Posttranslational modification, protein turnover, chaperones0
Ach15g153861.2Ach15g153861Uncharacterized protein0
Ach18g166421.2Ach18g166421Uncharacterized protein0
Ach18g424331.2Ach18g424331Posttranslational modification, protein turnover, chaperones0
Ach21g284861.2Ach21g284861Posttranslational modification, protein turnover, chaperones0
Ach24g203431.1Ach24g203431Uncharacterized protein0
Ach27g353711.2Ach27g353711Posttranslational modification, protein turnover, chaperones0